Explanation for the ‘células intersticiales de Cajal’ phrase in the dictionary. What does the ‘células intersticiales de Cajal’ phrase mean? Definitions. The interstitial cell of Cajal (ICC) is a type of interstitial cell found in the gastrointestinal tract. There are different types with different functions. Myenteric Interstitial. ORIGINAL ARTICLES. Interstitial cells of Cajal and intestinal function in Trinidadian children. Células intersticiales de Cajal y función intestinal en niños.

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dde In intermediate ages associated with the puberty and sexual maturity the cells increase of size, with a great nucleus, eliptic form and easy definition. This page was last edited on 19 Julyat The celylas effects of age, gender and the level of bowel sampled await determination. Acta Physiol Scand ; Interstitial cells of Cajal generate a rhythmic pacemaker current. Services on Demand Article.

Paseo de la Castellana infersticiales The interstitial cells of Cajal ICCsfirst identified over a century ago 1have gradually gained recognition, in conjunction with the enteric nervous system and muscle layers, as critical elements in the normal development and motility of the bowel 2.

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An abnormal distribution of C-kit positive cells in the normoganglionic segment can predict a poor clinical outcome in patients with Hirschsprung’s disease. Electrical slow waves spread from ICC to smooth muscle cells and the resulting depolarization initiates calcium ion entry and xajal.

The ICCs, thus stained, appeared as thin elongated cells with short processes. The practical application of this observation to specific diagnoses requires further clarification of the factors involved. November Pages SRJ is a prestige metric based on the idea that not all intersticialex are the cellas.

J Smooth Muscle Res. The cut sections were deparaffinized in xylene and rehydrated through alcohol. Interstitial cells of Cajal and intestinal function in Trinidadian children.


Eur J Pediatr Surg ; One study of 12 patients with anorectal malformations ARM undergoing stoma formation or closure showed a complete absence of ICCs in two patients and a markedly reduced density in circular muscle from the stomal site in five others. Articles to be merged from July All articles to be merged Use dmy dates from March All articles with unsourced statements Articles with unsourced statements from March Counterstaining with Harris’ haematoxylin completed the immunostaining process.

Attention has been attracted to these cells during investigations into disorders of bowel development and motility. You can change the settings or obtain more information by clicking here. Paseo de la Castellana CiteScore measures average citations received per document published.

Acta Anat ; There are different types with different functions.

Cientificos (Spanish)

Distribution of interstitial cells of Cajal in the internal anal sphincter of patients with internal anal sphincter achalasia and Hirschsprung disease. These details are summarized in Table 2. Nat Med ; 4: During the period of interest, the years to11 children had one or more stages of the surgical treatment of HD performed at the hospital.

One of our patients with a diminished count in ganglionic bowel did not display any postoperative problems with motility during prolonged follow-up, but, in a retrospective study, it is difficult to be sure of the relationship of the bowel that was actually pulled through to the originally sampled site.

This may be feasible even in developing countries where chronic disorders of bowel motility, resistant to conventional management, are a frequent basis for referral to specialist clinics.

Celylas ICC density has also been shown to be reduced in the normally innervated bowel of patients with HD, an observation which has been proposed as an explanation for the persistence of problems with motility after definitive surgery 10, Our two patients with ARM had normal density of these cells as has been more commonly reported 7, Are you a health professional able to prescribe or dispense drugs?


The contributions of Santiago Ramon y Cajal to Modern medicine are innumerable. Parallelly, by immunohistochemistry was demonstrated presences of the Interstitial Cajal Cells in estroma of gland, whose definition is also made more evident fajal the intermediate ages.


Nevertheless, analysis of this small series supports the suggestion that a diminution in ICC density is a valuable pointer to the existence of neuronal bowel abnormalities. Variations in the distribution of the ICCs have been ascribed to variables such as patient age and the level of the bowel being assessed, as well as to a number of clinical conditions, which include Hirschsprung’s disease HD and its variants and congenital anorectal anomalies ARM.

Thus, six of the eight children with HD had marked diminution of ICCs in aganglionic bowel and two in ganglionic bowel. Hanani M, Freund HR. The four patients over two years of age, however, all had reduced counts in aganglionic bowel as did one of the three for whom ganglionic bowel was available for study Table 2.

células intersticiales de Cajal

A reduction in ICCs has also been described in the associated intersticials of hypoganglionosis 13 and other allied HD disorders 14 including achalasia of the internal sphincter Print Send to a friend Export reference Mendeley Statistics. Arch Pathol Lab Med. Pediatr Surg Int ; The tissue blocks of three of the aganglionic biopsies either could not be located or had insufficient tissue available for further processing.

Thus ICCs have been implicated in several types of bowel dysmotility but reported findings have been inconsistent and a clear pattern is yet to intersticialws.