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BRYOPHYLLUM PINNATUM PDF

Scientific Name. Bryophyllum pinnatum (Lam.) Oken. Synonyms. Bryophyllum calycinum Salisb. Cotyledon pinnata Lam. Crassula pinnata L. f. Kalanchoe. Bryophyllum pinnatum (Lam.) Kurz (Crassulaceae) is a perennial herb growing widely and used in folkloric medicine in tropical Africa, tropical America, India. Objectives: To study the effect of Bryophyllum pinnatum (Lam.) leaf extracts viz. petroleum ether, alcohol and water on healing of excision, resutured incision and .

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Cancer patients frequently suffer from poor sleep quality.

Bryophyllum pinnatum – Wikipedia

Bryophyllum pinnatum is a herbal medication used in anthroposophic medicine, which has been shown to be associated bryophylluj improvements in sleep quality during pregnancy with only few and minor or moderate side-effects reported. In this study, the sleep quality of cancer patients during treatment with B pinnatum was investigated. Possible adverse drug reactions perceived by the patients during the treatment were recorded. From the 28 recruited patients, 20 completed both questionnaires and were considered in the present analysis.

There was no change in FSS. No serious adverse drug reactions were detected. B pinnatum may be a suitable treatment for sleep problems of cancer patients. Controlled, randomized clinical trials of the use of B pinnatum in sleep disorders are urgently needed. Cancer patients suffer frequently from poor sleep quality, which is often associated with worries, coping with illness, pain, and treatment side effects. While or after undergoing cancer therapies, the most common symptoms cancer patients experience include excessive fatigue, leg restlessness, insomnia, and increased sleepiness.

This and the fact that cancer patients often take several medications, some of which are associated with numerous and bruophyllum side-effects, makes the search for new, effective, and well-tolerated medications for sleeping problems worthwhile. Bryophyllum pinnatum Lamarck Oken [syn.: Kalanchoe bryophyolum Lamarck Persoon, syn.: Bryophyllum calycinum Salisbury] is a plant of the family Crassulaceae. It is originally from Madagascar but can now be found across tropical Africa, tropical America, India, China, and Australia.

Leaf extracts from B pinnatum have been pinnatun in traditional medicine of the regions where it grows and are suggested to have the following properties: Irrespective of the indication preterm contractions, 18 overactive bladder, 23 and sleep problems during pregnancy 25all clinical studies documented a good tolerability of B pinnatum. This favorable tolerability, the previous observational study on pregnant women, and the particular vulnerabilities of cancer patients prompted us to conduct the present observational, prospective study on the treatment of cancer-related sleeping problems with B pinnatum.

The suspected anticancer properties of B pinnatum preparations were not addressed in the present study; they are however reassuring inasmuch as a possible disadvantageous impact of the extracts on tumor progression can be ruled out.

This prospective, observational study was authorized by the ethical committee of canton of Zurich as well as by the Swiss Agency for Therapeutic Products and was performed according to good clinical practice.

Written informed consent was obtained from all study participants. At the beginning of the study, an additional exclusion criterion was treatment with soporifics affecting 11 patients ; after an authorized amendment to the study protocol, this criterion was replaced by bryohyllum change in the dosage of medication likely to affect sleep quality, either during the 3 weeks before the study started or during the study period.

By analogy with the previous observational study on pregnant women, the study had been designed to include 50 patients.

An analysis of the main outcomes was performed and the data are presented here. A voucher specimen of B pinnatum plants provided by Weleda, Brazil No. Previous analytical work on the pressed juice of fresh or fresh frozen B pinnatum leaves, which are routinely used to manufacture B pinnatum chewable tablets, revealed the presence of flavonoid glycosides as major constituents, and several bufadienolides as minor components. A detailed questionnaire was completed by the participants on day 1 before treatment with B pinnatum and on day 22 at the end of 21 days of treatment.

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For each question, the total number of answers n is shown, if different from From February until March28 patients were recruited, of whom 21 finished the study. The reasons for study dropout were the following: Hence, data from 20 patients could be evaluated. All 20 evaluated patients filled in the questionnaire at the beginning of the treatment and 3 weeks later.

The main demographic characteristics and disease characteristics of these patients are depicted in Table 1. The mean patient age was 61 years. The majority lived with a partner, were of female gender, were postmenopausal, exhibited a normal body mass index, had additional diseases other than cancerand were taking other medications. All patients complained of sleep disorders or changes in sleep behavior one of the inclusion criteriabryopyllum were mostly long-lasting 2 years on average, median 1 year.

Concerning the malignant disease, most patients were suffering from breast cancer, were in remission, and had a favorable ECOG performance status. Most patients had undergone several cancer-related therapies in the past more than 1 month before the study ; in the month prior to the pinnatmu as well as during the study, mistletoe therapy was the most frequently mentioned therapy.

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During treatment with B pinnatumsleep quality of the participating cancer patients improved markedly, inasmuch as a statistically significant reduction of PSQI was observed from It should be kept in mind that the higher the values of the global PSQI and of the corresponding componentsthe worse the sleep quality.

When the different PSQI components were compared at the beginning and at the end of the treatment Figure 2improvements of subjective sleep quality 1. A tendency for an improvement was observed in the case bryophyyllum sleep duration 1. No significant alteration was detected in daytime dysfunction 1. Most components of the Pittsburgh Sleep Quality Index improved during treatment of cancer patients with B pinnatum for 3 weeks. On the other hand, no alteration in fatigue could be observed during pinnagum study period A few discomforts, all of minor severity, were reported by patients to be possibly caused by the study medication see Table 1.

They consisted of fatigue, dry throat, agitation, and difficult digestion. No severe adverse reactions were reported by any patient at any time. One patient in the perimenopausal period reported personally on her own initiative bdyophyllum clear-cut improvement in hot flashes.

Some of the symptoms triggered by a cancer disease and initial treatment, for example, sleep disturbances and fatigue, are long-lasting, with cancer survivors experiencing them even more than 10 years bdyophyllum. Indeed, the average baseline Bryophyllmu of 12 is relatively high in comparison with values from other studies often 32 – 35 is reported among breast cancer patients, or 8 for elderly patients 36rather corresponding to the value initially plnnatum among depressive patients. This averaged index decreased from 12 to 9 during treatment, which is likely to be clinically relevant, even though most patients did not attain values characteristic of good sleepers at the end of the study.

Whether a 3-point improvement renders the sleep problems of cancer patients such as those of the present study bearable or whether additional treatments should be followed requires further investigation.

However, a 3-point improvement compares well with differences of 1 to 1. In the present study, all PSQI components but one—daytime dysfunction—were higher at study beginning than after 3 weeks of treatment, suggesting a manifold improvement. The present observations corroborate the results obtained in the former prospective clinical study about the effect of B pinnatum on sleep quality during pregnancy. Taken together, the 2 studies indicate that B pinnatum is effective for multiple types of sleep problems.

The improvements in PSQI observed here are highly statistically significant even though the number of patients was smaller than initially planned and in comparison with the previous study 20 vs This suggests byophyllum the improvements were more clear-cut than initially expected.

Cancer patients suffer not only from sleep problems at night but bbryophyllum from daily sleepiness and bryopuyllum.

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Comparable results bryophyllu obtained in bryopbyllum previous study with pregnant women. These results must be interpreted in view of the study population, which at treatment beginning exhibited initial FSS scores only slightly higher than those typical for healthy subjects, that is, up to Indeed, only in one of these cases were concomitant increases in FSS and in daytime dysfunction during the pinnaatum period detected data not shown.

The main limitation of this study is the lack of a control group and patient randomization, which prevents the demonstration of a causal relationship between intake of B pinnatum and improvement of sleep quality.

Herbal medications, such as those prepared from B pinnatumare often multitarget medicines with a pleiotropic effect profile. In other words, possible improvements in some of these co diagnoses might have contributed to the observed improvements in sleep quality and daily sleepiness.

Whereas this multitude of possible indications might shed some doubts on which might be the exact condition that was most improved during treatment with B pinnatumit can be clinically advantageous. The example of the patient who took the initiative of reporting an improvement in hot flashes illustrates this pragmatic perspective.

The present work shows that the sleep quality of cancer patients significantly improved under treatment with B pinnatum and that this medication was well tolerated in this clinical context. The significant and additionally observed favorable effect of B pinnatum on daytime sleepiness may be associated with the improvement in sleep quality and turned out to be independent of fatigue, which did not change during the study.

No serious adverse event occurred during treatment. We express our gratitude to the participating patients and thank the bryophylllum clinic Paracelsus-Hospital Richterswil for the opportunity to perform this study. We thank Claudia Lambrigger-Steiner, who contributed to the elaboration of the study documents and Heather Murray for language corrections. Weleda AG Arlesheim, Switzerland provided the Bryophyllum pinnatum tablet medication free of charge to the study participants.

In addition to A. Potterat, PhD, and Bryopnyllum. Declaration of Conflicting Interests: National Center for Biotechnology InformationU.

Author information Copyright and License information Disclaimer. Introduction Cancer patients suffer frequently from poor sleep quality, which is often associated with worries, coping with illness, pain, and treatment side effects. Pinnatu and Methods Study Design This prospective, observational study was authorized by the ethical committee of canton of Zurich as well as pinntaum the Swiss Agency for Therapeutic Products and was performed according to good clinical practice.

Measurements A detailed questionnaire was completed by the participants on day 1 before treatment with B pinnatum and on day 22 at the end of 21 days of treatment. Results From February until March28 patients were recruited, of whom 21 finished the study. Open bryophtllum a separate window. Discussion Some of the symptoms triggered by a cancer disease and initial treatment, for example, sleep disturbances and fatigue, are long-lasting, with cancer survivors experiencing them even more than 10 years thereafter.

Conclusion The present work shows that the sleep quality of cancer patients significantly improved under treatment with B pinnatum and that this medication was well tolerated in this clinical context. Acknowledgments We express our gratitude bryophyllim the participating patients and thank the outpatient clinic Paracelsus-Hospital Richterswil for the opportunity to perform this study.

Sleep-related problems in common medical conditions. Int J Psychiatry Med.

Sleep disturbance in cancer patients. Kamboj A, Saluja A. Bioactive molecules in Kalanchoe pinnata leaves: Wound healing potential of ethanolic extract of Kalanchoe pinnata Lam.

Indian J Bryophhyllum Biol. Antihyperglycaemic potential of the water-ethanol extract of Kalanchoe crenata Crassulaceae. Antinociceptive, anti-inflammatory and antidiabetic effects of Bryophyllum pinnatum Crassulaceae leaf aqueous extract.

Anticancer property of Bryophyllum pinnata Lam. Neuropsychopharmacological profile of the methanolic fraction of Bryophyllum pinnatum leaf extract.