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(PDF) 74645 Datasheet download
The more charged residues on a peptide, the more soluble it is in aqueous solutions. DMSO, then dilute using water or buffer. If a peptide does not dissolve and you need to recover it, lyophilise to datashedt the solvent.
Datasheet, PDF – Alldatasheet
If the solution is cloudy or 7645 gelled the peptide may be in suspension rather than solubilised. Target information above from: Publishing research using ab?
CQ 1520 Details
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Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA.
Contributes to datwsheet regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors By similarity. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA in vitro.
May play a role in DNA repair.
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The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. In the absence of phosphorylation the protein is retained in the cytoplasm. Cleaved by a 20S proteasomal protease in response to agents that damage DNA. Cleavage takes place in the absence of ubiquitination dagasheet ATP.
The resulting N-terminal fragment accumulates in the nucleus. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating satasheet. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Secreted by mesangial and monocytic cells after inflammatory challenges.
Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress. Submit a review Submit a question. Highest votes Sort by: Lowest votes Sort by: Newest First Sort by: Elisa Thomas Abcam Scientific Support.
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